Single Use Mixing System Solution

Single use mixing systems are used in the pharmaceutical industry to mix homogeneous liquids and solids. It can be roughly divided into three applications: liquid-liquid mixing, solid-liquid mixing, and solid solid mixing. The application of sterile pharmaceutical downstream processes is becoming increasingly widespread, covering chemical drugs, protein drugs, vaccines, and more. The process points used have also advanced from sterile preparations to intermediate storage regulation, and extended to key steps such as downstream virus inactivation.

What is a single Use Mixing System?

Single use stirring systems are used in the pharmaceutical industry to mix homogeneous liquids and solids. It can be roughly divided into three applications: liquid-liquid mixing, solid-liquid mixing, and solid solid mixing. The application of sterile pharmaceutical downstream processes is becoming increasingly widespread, covering chemical drugs, protein drugs, vaccines, and more. The process points used have also advanced from sterile preparations to intermediate storage regulation, and extended to key steps such as downstream virus inactivation. The so-called single use refers to the use of mixing bags made of single use film materials, pipelines, joints and other accessories to complete mixing, eliminating the need for cleaning, disinfection, sterilization, verification and other processes of stainless steel products. It is disposable after use, convenient and fast, while meeting relevant process requirements.

What are the main types of single use mixing systems?

The single use stirring system mainly includes mechanical shaft stirring system, magnetic stirring system, and swing reaction system. The following content will be introduced in detail:

1. Mechanical shaft mixing system

Mechanical shaft mixing is divided into three modes: open top mixing, closed top mixing, and bottom mixing.

*Open top mixing - equipped with a mechanical stirring blade at the top, driven by a motor to rotate the mechanical shaft, so that the blade can stir and mix liquid-liquid or solid-liquid in a single use mixing bag, used in conjunction with a single use 2D open top mixing bag.

*Closed end stirring - Use a stirring rod and place it in a silicone sleeve with an inner tube closed, so that it does not come into contact with the liquid. Drive the mechanical shaft to rotate through a motor, so that the stirring rod can stir and mix the liquid-liquid or solid-liquid in a single use stirring bag, and use it with a single use 3D closed stirring bag.

*Bottom stirring - The bottom is equipped with mechanical stirring blades, which are driven by a motor to rotate the mechanical shaft, allowing the blades to stir and mix liquid-liquid or solid-liquid in a single use mixing bag. Compared to the top stirring mode, the bottom stirring system is less limited by the height of the processed liquid level, but requires higher mechanical shaft sealing requirements. The mixing effect mainly depends on the comprehensive parameters such as the shape, size, and speed of the blade. As it is driven by a motor, in general, the higher the output power, the better the stirring effect, and it can be used for mixing viscous and difficult to stir materials.

2. Magnetic stirring system

The single use magnetic stirring system mainly consists of a rigid support system, a drive system, a weighing system, a control system, a data output system, and sensors or instruments. The main purpose is to provide a three-dimensional solution for efficient and rapid solid-liquid and liquid-liquid mixing through stirring, weighing, temperature control, pH monitoring, etc. The bottom magnetic stirring unit is divided into integrated drive and split drive. The single use magnetic stirring system is a modular system that allows customers to selectively match the required functions. It is currently widely used in the preparation of culture media, buffer solutions, purification of intermediate products, and semi-finished product preparation.

Single use magnetic stirring bag

Advantages ◗

● Buffer preparation, culture medium preparation, intermediate mixing, virus inactivation, semi-finished product preparation, vaccine adjuvant mixing.

Application ◗

The driving unit transmits power through magnetic coupling without direct contact with liquids, ensuring sterility.

The size and speed of the stirring blade can be adjusted according to the process to ensure more thorough and uniform mixing of the solution.

The mixing bag is disposable, requires no cleaning, improves efficiency, and saves costs.

Diagram of Magnetic Stirring System

Advantages ◗

The equipment bracket and supporting container are made of 304 stainless steel and have a brushed surface treatment.

The stirring blade inside the disposable magnetic stirring bag is driven by a magnetic coupling motor for stirring. There is no mechanical seal, no stirring shaft penetrating the tank body, and no lubricating oil. No particulate matter is generated during stirring, reducing the risk of pollution.

PLC control, stable control, easy and simple operation.

Easy to install, use, and maintain.

One person can build the entire mixing system within 5 minutes.

Modular design, develop different solutions according to different needs, such as conductivity, pH, temperature, weighing and other functions.

Application ◗

● Buffer preparation and mixing of intermediates.

Equipped with multiple Federal Reserve liquid bags and multi-layer liquid storage vehicles

(Can be applied to mechanical shaft stirring systems and magnetic stirring systems)

3. Swing reaction system

The swing reaction system consists of a single use pillow bag and a swing platform. The single use pillow shaped bag is filled with liquid and placed on a swinging platform. The liquid moves in a regular forward and backward or orbital motion through the swinging platform, forming waves on the surface of the liquid to achieve a mixing effect. The single use bioreactor bag used in conjunction with the swing reaction system is mainly composed of accessories such as 9101 membrane, tubing, and connectors. Closed cultivation provides a suitable environment for cell growth while minimizing the risk of cross contamination. The material is transparent and flexible, making it easy to directly observe cell dynamics under a microscope and achieving excellent cell culture of sensitive cell lines.

Advantages ◗

Ready to use and disposable, no cleaning required, improving efficiency and saving costs.

● High physical performance, excellent chemical compatibility, and biocompatibility.

● Flexible customization of sizes, pipelines, and fittings.

● Aseptic and non-toxic, in compliance with GMP standards.

Application ◗

Mixing, packaging, storage, transportation, and cell culture of solutions.

Antibodies, vaccines, cell therapy, gene therapy, etc.

Technical parameters ◗