The Critical Role of Automated Sampling in Dissolution Testing

Introduction In dissolution testing, timing is everything. Taking a sample even 30 seconds late can significantly alter the dissolution curve, leading to false failures in kinetic studies.

The Automated Sampling Solution Automated sampling systems integrated with dissolution testers (like the RCZ series) provide:

• Zero-Delay Sampling: Simultaneous withdrawal from 6 or 8 vessels.

• Standardized Filtration: Inline filters ensure that no undissolved particles continue to dissolve after the sample is taken.

• Direct HPLC Injection: Some systems can transfer samples directly to an HPLC vial, eliminating human transfer errors.